Effects of Hyaluronan on Proliferation and Differentiation Cultured Chondrocyte / 대한정형외과연구학회지

OBJECTIVES: Recent basic science studies continue to further our understanding of the fundamental mechanisms that likely underlie the therapeutic benefits of hyaluronan derivatives. The purpose of this study is to elucidate the effects of hyaluronan on ATDC5 proliferation and differentiation. METHODS: ATDC5 cells derived from mouse teratocarcinoma have the capacity to differentiate along a number of connective tissue pathways and are an attractive source of chondrocyte precursor cells. In this study, hyaluronan influencing ATDC5 chondrogenesis were investigated using an bone block culture system. The cell proliferation was analyzed by MTT assay. To validate ATDC5 differentiation we studied ALP activity, collagen content and western blot of Hsp40. RESULTS: In cell proliferation, ATDC5 cells didn't show significant difference between controls and hyaluronan-treated cultures. But hyaluronan induced ALP activity and increased collagen accumulation. Hyaluronantreated ATDC5 cells expressed Hsp40 mRNA and protein within 24 hours. CONCLUSIONS: Hyaluronan-induced chondrogenic differentiation was not associated with ATDC5 cell proliferation. Hyaluronan-induced Hsp40 in cells can protect the cell function from damaged protein. These data provide new insights into regulatory mechanism defining pharmacological effects of hyaluronan.

The Correlation between Outcome Evaluation Systems after Anterior Cruciate Ligament Reconstruction

PURPOSE: The purpose of this study was to evaluate the correlation between various subjective, objective tests and real functional performances of the patients after ACL reconstruction. METHOD: Twenty-four patients after ACL reconstruction using 12 hamstring autograft and 12 Achilles allograft were evaluated. Lysholm knee score, IKDC subjective score, Knee Outcome Survey score and Tegner activity score were evaluated for the subjective outcome value. Static instability tests, Biodex dynamometer and hop tests were done for the objective outcome value. Three functional performance tests(FPTs) such as carioca test, shuttle run test and co-contraction test were done for deciding the real performance ability of the patients. Each score system was compared with FPT results. RESULTS: The results of Hamstring group were better than those of Achilles group, but there was no statistical significance. IKDC subjective score, single leg hopping test, and quadriceps power in low velocity of biodex dynamometer tests had a positive correlation with the total FPT results. CONCLUSION: IKDC subjective score, one leg hopping test showed significant correlation with functional performance test and they can be used as effective methods to decide whether the subjects after ACL reconstruction can return to sports activity.

A Radiographic Analysis of the Feet in Heel Pain / 대한족부족관절학회지

PURPOSE: This study is to compare the medial longitudinal arch between heel pain group and normal painless group. MATERIALS AND METHODS: Heel pain group 242 feet and normal group 140 feet were evaluated through the radiographic images of standing foot-ankle lateral view. Four radiographic indices, talo-1stmetatarsal angle (TMA), calcaneal-1st metatarsal angle (CMA), calcaneal pitch angle (CPA), and arch ratio (AR), were used as well as BMI. RESULTS: There was no difference between heel pain group and normal group in the TMA, CMA, CPA, and AR. But in the BMI, heel pain group showed 1.7 kg/m2 (p=0.0002) higher than normal group. To eliminate the sexual error, male and female were evaluated separately. Male heel pain group showed 2.9 degrees more dorsiflexion (p=0.001) in the TMA, 3.1 degrees greater (p=0.007) in the CMA, 0.01 lower (p=0.028) in the AR, and 1.0 kg/m2 greater (p=0.033) in the BMI than normal male group. There were no difference in the CPA. Female heel pain group showed 3.6 degree greater (p=0.035) in the CMA, and 1.9 kg/m2 greater (p=0.002) in the BMI than normal female group. But other indices demonstrated no differences. CONCLUSION: talo-1stmetatarsal angle, calcaneal-1st metatarsal angle and arch ratio were radiographic indices related with heel pain.

A Radiographic Analysis of the Feet in Heel Pain / 대한족부족관절학회지

PURPOSE: This study is to compare the medial longitudinal arch between heel pain group and normal painless group. MATERIALS AND METHODS: Heel pain group 242 feet and normal group 140 feet were evaluated through the radiographic images of standing foot-ankle lateral view. Four radiographic indices, talo-1stmetatarsal angle (TMA), calcaneal-1st metatarsal angle (CMA), calcaneal pitch angle (CPA), and arch ratio (AR), were used as well as BMI. RESULTS: There was no difference between heel pain group and normal group in the TMA, CMA, CPA, and AR. But in the BMI, heel pain group showed 1.7 kg/m2 (p=0.0002) higher than normal group. To eliminate the sexual error, male and female were evaluated separately. Male heel pain group showed 2.9 degrees more dorsiflexion (p=0.001) in the TMA, 3.1 degrees greater (p=0.007) in the CMA, 0.01 lower (p=0.028) in the AR, and 1.0 kg/m2 greater (p=0.033) in the BMI than normal male group. There were no difference in the CPA. Female heel pain group showed 3.6 degree greater (p=0.035) in the CMA, and 1.9 kg/m2 greater (p=0.002) in the BMI than normal female group. But other indices demonstrated no differences. CONCLUSION: talo-1stmetatarsal angle, calcaneal-1st metatarsal angle and arch ratio were radiographic indices related with heel pain.

Results of Ludloff Osteotomy in Hallux Valgus / 대한족부족관절학회지

PURPOSE: The purpose of this study was to evaluate the outcome of Ludloff osteotomy for treatment of hallux valgus with regard to patient satisfaction and clinical and radiological results. MATERIALS AND METHODS: 43 feet of 28 patients underwent Ludloff osteotomy between January 2003 and August 2003. 21 patients (32 feet) who were available for follow up for more than one year were enrolled in this study. Average follow up period was 16 months. All patients were female and the average age was 51 years ranging 28 years to 72 years. Patient satisfaction was assessed and VAS (Visual Analogue Scale) was used for subjective outcome, AOFAS (American Orthopaedic Foot and Ankle Society) score and presence of metatarsalgia were used for clinical outcome, and hallux valgus angle and intermetatarsal angle were used for radiological outcome assessment. RESULTS: Patient satisfaction regarding cosmesis was excellent in 6 cases, good in 21 cases, fair in 4 cases and poor in 1 case. VAS was improved from preoperative 6 points to postoperative 2 points and AOFAS score was improved from preoperative 53 points to postoperative 82 points. Metatarsalgia was observed in 18 cases preoperatively and 9 cases postoperatively. HVA and IMA were 35.8 and 15.2 degrees preoperatively, 12.5 and 6.6 degrees at 3 months follow up, and 13.2 and 7.1 degrees at last follow up respectively. At the last follow up, loss of angle of correction for HVA was 0.7 degrees and for IMA was 0.5 degrees. CONCLUSION: Ludloff osteotomy is an appropriate surgery of moderate to severe hallux valgus.

Results of Ludloff Osteotomy in Hallux Valgus / 대한족부족관절학회지

PURPOSE: The purpose of this study was to evaluate the outcome of Ludloff osteotomy for treatment of hallux valgus with regard to patient satisfaction and clinical and radiological results. MATERIALS AND METHODS: 43 feet of 28 patients underwent Ludloff osteotomy between January 2003 and August 2003. 21 patients (32 feet) who were available for follow up for more than one year were enrolled in this study. Average follow up period was 16 months. All patients were female and the average age was 51 years ranging 28 years to 72 years. Patient satisfaction was assessed and VAS (Visual Analogue Scale) was used for subjective outcome, AOFAS (American Orthopaedic Foot and Ankle Society) score and presence of metatarsalgia were used for clinical outcome, and hallux valgus angle and intermetatarsal angle were used for radiological outcome assessment. RESULTS: Patient satisfaction regarding cosmesis was excellent in 6 cases, good in 21 cases, fair in 4 cases and poor in 1 case. VAS was improved from preoperative 6 points to postoperative 2 points and AOFAS score was improved from preoperative 53 points to postoperative 82 points. Metatarsalgia was observed in 18 cases preoperatively and 9 cases postoperatively. HVA and IMA were 35.8 and 15.2 degrees preoperatively, 12.5 and 6.6 degrees at 3 months follow up, and 13.2 and 7.1 degrees at last follow up respectively. At the last follow up, loss of angle of correction for HVA was 0.7 degrees and for IMA was 0.5 degrees. CONCLUSION: Ludloff osteotomy is an appropriate surgery of moderate to severe hallux valgus.

Arthroscopic Evaluation of Posterolateral Rotatory Instability of the Knee / 대한정형외과학회잡지

PURPOSE: The purpose of this study was to confirm the efficacy of arthroscopic findings for the diagnosis of posterolateral rotatory instability (PLRI) of the knee. MATERIALS AND METHODS: We retrospectively evaluated 27 patients (28 cases) who had been operated upon for PLRI between February 1998 and June 2001. All patients underwent preoperative or intraoperative arthroscopic examinations including anterior/posterior cruciate ligament, popliteus tendon, inferior and superior popliteomeniscal fascicle, popliteofibular ligament, lateral meniscus, instability and abnormal popliteomeniscal motion for internal and external rotation. RESULTS: Instability, which means popliteal hiatus widening during internal rotation of the tibia, was identified in all cases (100%). Tear of the inferior and superior popliteomenical fascicle was identified in 24 cases (86%) and abnormal popliteomeniscal motion during rotation was identified in 20 cases (71%). Popliteus tendons were abnormal in 18 cases (65%) with 5 cases (19%) of complete tear and 13 cases (46%) of partial tear or elongation. CONCLUSION: These results suggest that arthroscopic evaluation of the popliteal hiatus structures in the patients suspected for PLRI of the knee is helpful for diagnosis and the determination of treatment modality.

Evaluation of the Elmslie-Trillat-Marquet Procedure for Recurrent Patellar Subluxation or Dislocation / 대한정형외과학회잡지

PURPOSE: To assess the clinical and radiographic results of the Elmslie-Trillat-Marquet procedure used to treat recurrent patellar subluxation or dislocation with patellar malalignment. MATERIALS AND METHODS: A total of 15 knees in 14 patients were evaluated at an average of 54.5 months (12 to 106) following the Elmslie-Trillat-Marquet procedure; carried out between May 1993 and March 2000. The evaluation included subjective, objective and radiographic assessments. RESULTS: The causes of recurrent patella dislocation were patella alta (11 knees), tight lateral retinaculum (8 knees), patella dysplasia (7 knees), femoral condyle dysplasia (13 knees) and joint hyperlaxity (1 case). The average preoperative Q-angle was 28.5degrees and the postoperative angle 13 degrees. Subjective evaluation using Cox's criteria showed excellent or good results in 13 knees (87%), and the objective evaluation using Fulkerson's functional knee score showed excellent or good results in 14 knees (93%). The mean anterior tibial tubercle displacement was 8 mm (7-11 mm), and the patella congruence angle and Insall-Salvati index were significantly corrected (p<0.001). Lateral subluxation and patellar tilt angle were corrected in all cases. The only complication was an irritation due to nonabsorbable suture material. There were no redislocations, infections, nonunions, or fractures of the transferred tibial tubercle during the follow-up period. CONCLUSION: The Elmslie-Trillat-Marquet procedure for recurrent patellar subluxation or dislocation can basically correct malalignment tridimensionally.

Revision Total Hip Arthroplasty Using Allogenic Chip Bone Grafts and Cement in Acetabular Bone Deficiencies: Minimum Two Year Clinical and Radiological Analysis / 대한정형외과학회잡지

The purpose of this study was to analyze the minimum two year clinical and radiological results of revision total hip arthroplasties using allogenic chip bone graft and cement in acetabular bone deficiencies. Thirty six revision total hip arthroplasties that had been performed in thirty four patients between Sep. 1992 and May. 1994 at Seoul Paik Hospital and had followed more than two years were included in this study. The clinical result was evaluated by Harris hip score. The mean Harris hip score was 48 points preoperatively, 88 points at final follow-up, a mean of 3 years after revision. In radiological evaluation, osseous union between grafted bone and host bone was seen within 4 months in thirty two hips (89%), a complete grafted bone-cement radiolucent line of two millimeter or more in at least one zone was seen in seven hips (19%) and acetabular component migration was seen in six hips (17%) at postoperative 3 year follow-up radiograph. At the time of follow-up, five hips (14%) had been revised a second time: three for aseptic acetabular loosening, two for infection. In conclusion, we recommend the technique using allogenic chip bone graft and cement to reconstruct the acetabular bone deficiencies in revision total hip arthroplasties, though other technique will be recommend in severe segmental acetabular deficiencies or previous infection.